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Synthesis of [1,4]dioxino[2,3-c]quinolines and [1,4]dioxepino-[2,3-c]quinolines and their 1-sulfur analogues

✍ Scribed by Romana Hiessböck; Martin Kratzel

Publisher: Journal of Heterocyclic Chemistry
Year: 1999
Tongue: English
Weight: 495 KB
Volume: 36
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570360530

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✦ Synopsis

Abstract

The synthesis of [1,4]dioxino[2,3‐c]quinolines and [1,4]dioxepino[2,3‐c]quinolines with restrained conformation of the piperidine ring, which represent 1,2,3,4‐tetrahydroquinolines containing two heteroatom substituents at positions 3 and 4, is described. In addition, the application of this approach for the synthesis of 1‐sulfur analogues is discussed. Both series are helpful tools for three‐dimensional quantitative structure‐activity relationship studies in the field of modulators of multidrug resistance.

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