Pyrrolo[3,4-c]quinoline-1,3-diones as Potent Caspase-3 Inhibitors. Synthesis and SAR of 2-Substituted 4-Methyl-8-(morpholine-4-sulfonyl)-pyrrolo[3,4-c]quinoline-1,3-diones.
β Scribed by Dmitri V. Kravchenko; Volodymyr M. Kysil; Sergey E. Tkachenko; Sergey Maliarchouk; Ilya M. Okun; Alexandre V. Ivachtchenko
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 12 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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Some pyrazolo[3,4-c~quinoline-4-ones 1-14 and pyrazolo[3.4-c]quinoline-I ,4-diones 15-17 were prepared and biologically evaluated for their binding at the benzodiazepine receptor (BZR) in rat cortical membranes. The moderate binding activity of 1-5,7,9-10, 13 is attributable to the lack of the optio