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Synthesis of 14C-labelled 3-(1-hydroxy-2-piperidinoethyl)-5-phenylisoxazole citrate (31252-S)

✍ Scribed by H. Minato; T. Nagasaki; T. Yokoshima; K. Suga; M. Yamaguchi

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
268 KB
Volume
10
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

3‐(1‐Hydroxy‐2‐piperidinoethyl)‐5‐phenylisoxazole citrate, 31252‐S (I) has been labelled with carbon‐14. The carbon‐14 label was incorporated into the C‐2 position of the side‐chain to give (II) and into the C‐4 position of the isoxazole ring of the molecule to give (III).

The carbon‐14 labelled products (II) and (III) were obtained in 27% and 6.4% ratiochemical yield based on methyl iodide‐^14^C, respectively.

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