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Synthesis of 14C-labelled 10-[3-(dimethylamino)-propyl]-2-nitrodibenz [b,f] [1,4] oxazepin-11-(10 H)-one (nitroxazepine)hydrochloride

✍ Scribed by R. K. Maller; K. Nagarajan

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
321 KB
Volume
20
Category
Article
ISSN
0022-2135

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✦ Synopsis

For pharmacokinetic and metabolism s t u d i e s i n a n i m a l s and humans, n i t r o x a z e p i n e , an a n t i d e p r e s s a n t , was l a b e l l e d w i t h carbon-14 a t t h e 1 1 -p o s i t i o n of t h e dibenzoxazepine r i n g system i n an o v e r a l l y i e l d of 12A s t a r t i n g w i t h potassium [I4C] cyanide. The l a b e l l e d p r e p a r a t i o n had a s p e c i f i c a c t i v i t y of 0.95 yCi/mg.

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