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Synthesis of 1,4-diarylsubstituted 1,3-diynes through ligand-free copper-catalyzed oxidative decarboxylative homocoupling of aryl propiolic acids

✍ Scribed by Liu, De-Xian; Li, Fei-Long; Li, Hong-Xi; Gao, Jun; Lang, Jian-Ping


Book ID
121752038
Publisher
Elsevier Science
Year
2014
Tongue
French
Weight
1002 KB
Volume
70
Category
Article
ISSN
0040-4020

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One-pot synthesis of 1,4-diarylsubstitut
✍ Yong Kim; Ahbyeol Park; Kyungho Park; Sunwoo Lee πŸ“‚ Article πŸ“… 2011 πŸ› Elsevier Science 🌐 French βš– 645 KB

1,4-Disubstituted 1,3-dialkynes were obtained from the one-pot palladium/copper-catalyzed coupling reactions of aryl iodide and propiolic acid. The optimized catalytic system consisted of 5.0 mol % Pd(PPh 3 ) 2 Cl 2 , 10 mol % dppb, 10 mol % CuI, 2.4 equiv of DBU, and 1.2 equiv of K 2 CO 3 . The cou