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Pd-Catalyzed Decarboxylative Coupling of Propiolic Acids: One-Pot Synthesis of 1,4-Disubstituted 1,3-Diynes via Sonogashira−Homocoupling Sequence

✍ Scribed by Park, Jihye; Park, Eonjeong; Kim, Aejin; Park, Seul-A; Lee, Youngil; Chi, Ki-Whan; Jung, Young Hoon; Kim, In Su


Book ID
115311454
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
938 KB
Volume
76
Category
Article
ISSN
0022-3263

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✍ Yong Kim; Ahbyeol Park; Kyungho Park; Sunwoo Lee 📂 Article 📅 2011 🏛 Elsevier Science 🌐 French ⚖ 645 KB

1,4-Disubstituted 1,3-dialkynes were obtained from the one-pot palladium/copper-catalyzed coupling reactions of aryl iodide and propiolic acid. The optimized catalytic system consisted of 5.0 mol % Pd(PPh 3 ) 2 Cl 2 , 10 mol % dppb, 10 mol % CuI, 2.4 equiv of DBU, and 1.2 equiv of K 2 CO 3 . The cou