Six healthy volunteers were given single doses of amitriptyline (AT) and of nortriptyline (NT) separated by at least 10 days. Plasma concentrations of both compounds were measured at intervals for 48 or 72 h. The total areas under the concentration-time curves for the ingested drug were greater for
โฆ LIBER โฆ
Synthesis of [13C2]-amitriptyline, nortriptyline and desmethylnortriptyline
โ Scribed by I. Midgley; R. W. Pryor; D. R. Hawkins
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 356 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
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Methods for the estimation of the tricyclic antidepressants in plasma have been described employing UV spectrophotometry', gas-liquid chromatographyz4, and mass fragmentography5-6. UV methods, while adequate for analysis in cases of overdose, are insufficiently sensitive where plasma IeveIs are req