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Synthesis of 1,2,7,7a-Tetrahydro-1a H -cyclopropa[ b ]quinoline-1a-carboxylic Acid Derivatives, Doubly Constrained ACC Derivatives, by a Remarkable Cyclopropanation Process

✍ Scribed by Szakonyi, Zsolt; Fülöp, Ferenc; Tourwé, Dirk; De Kimpe, Norbert


Book ID
126423396
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
83 KB
Volume
67
Category
Article
ISSN
0022-3263

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Synthesis of benzyl (6S)-1,3-dichloro-4-
✍ Philippe Gloanec; Yolande Hervé; Nathalie Brémand; Jean-Pierre Lecouvé; Fabienne 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 69 KB

We describe the synthesis of benzyl (6S)-1, 3-dichloro-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic ester, a new conformationally constrained peptidomimetic derivative. This compound is prepared in seven steps from (S)-pyroglutamic acid as starting material.