Synthesis of 1,2,4-tri-O-acetyl-5-deoxy-5-C-[(R and S)-methoxy-phosphinyl]-3-O-methyl-α- and -β-d-xylopyranose, and their structural analysis by 400-MHz, proton nuclear magnetic resonance spectroscopy
✍ Scribed by Hiroshi Yamamoto; Tadashi Hanaya; Saburo Inokawa; Kuniaki Seo; Margaret-Ann Armour; Tom T. Nakashima
- Book ID
- 107725302
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 778 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0008-6215
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Various sugar analogs possessing a phosphorus atom in the hemiacetal ring have been preparedIe because of the interest in their physicochemical properties and also the potential utility of'their biological activity. Compared with a large number of the analogs having an alkyl-or aryl-phosphinyl group
5-Dcoxy-J,2-O-isopropylidene-S-C-(methoxyphenylphosphinyl)-~-O-~~thyl-n-D-ribofuranose (4) was prepared from 1,2-0-isopropylidene-3-O-methyl-a-D-ribo-pentodialdo-1,4-furanose by an addition reaction with methyl phenylphosphinate, followed by deoxygenation of the terminal HO-$H-P group of the adduct