Synthesis of 1,2,3,5-tetra-O-acetyl-4-deoxy-4-C-[(R,S)-ethylphosphinyl]-α,β-d-ribofuranoses: the first d-ribofuranose derivatives having phosphorus in the hemiacetal ring
✍ Scribed by Hiroshi Yamamoto; Yuhji Nakamura; Saburo Inokawa; Mitsuji Yamashita; Margaret-Ann Armour; Tom T. Nakashima
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 160 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0008-6215
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✦ Synopsis
We have previously reported' the synthesis of 1,2,3-tri-O-acetyGI,Sdideoxy-4-C-[(R,S)-phenylphosphinyl] -o&3-D-ribo-and -L-lyxo-furanoses (4) by the sequence of 1 -+ 2 + 3 + 4. However, this method could not be applied to a synthesis of 4deoxy-*To whom correspondence may be addressed.
📜 SIMILAR VOLUMES
Various sugar analogs possessing a phosphorus atom in the hemiacetal ring have been preparedIe because of the interest in their physicochemical properties and also the potential utility of'their biological activity. Compared with a large number of the analogs having an alkyl-or aryl-phosphinyl group
The preparation of a beta-galactosylated hydroxyproline derivative and its use in the multi-gram solid-phase synthesis of the potent analgesic neoglycopeptide O1.5-beta-D-galactopyranosyl [D-Met2, Hyp5]enkephalinamide is described in this paper. The most closely related impurities have been identifi