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Synthesis of 1,2-disubstituted-1,4,5,6-tetrahydropyrimidines

โœ Scribed by Isabel Perillo; Samuel Lamdan

Book ID
112123059
Publisher
Journal of Heterocyclic Chemistry
Year
1973
Tongue
English
Weight
348 KB
Volume
10
Category
Article
ISSN
0022-152X

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Alkylation of 1-(3,4-Disubstituted Phenyl)-2-thioxo-1,2,5,6tetrahydropyrimidin-4(3H)-ones. -Alkylation of the title compounds (I), (VI), and (IX) results in the formation of S-and N-methylated derivatives. S-methylated products (III), (VII), and (X) are always the major products. In all cases, meth