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Synthesis of 1,1-disubstituted tetrahydro-β-carbolines from 2-methyleneaziridines

✍ Scribed by Peter M. Mumford; Jason J. Shiers; Gary J. Tarver; Jerome F. Hayes; Michael Shipman

Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
114 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

Ring opening of indole functionalised methyleneaziridines (3a-c, 7) with alcohols in the presence of boron trifluoride etherate leads to the formation of 1,1-disubstituted tetrahydro-b-carbolines in moderate to good yields (37-83%).

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