Synthesis of 1-deoxy-4-thio-L-ribose starting from D-arabitol
โ Scribed by Hans-Josef Altenbach; Gerd F Merhof
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 152 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0957-4166
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๐ SIMILAR VOLUMES
The de novosynthesis of l-deoxy-4-thio-D-ribosestarting from thiophene-2-carboxylicacid is described. The key step is the cis-dihydroxylationof .S-2-acetoxy-2,5 -dihydrothiophene,which is obtainedby enzymaticalcoholysis. Q 1997Elsevier Science Ltd.
Synthesis of 1-Deoxy-4-thio-D-ribose Starting from Thiophene-2carboxylic Acid. -Key step in the synthesis of the title compound (V) is the cis-dihydroxylation of (S)-(II), obtained by enzymatic alcoholysis.
## Abstract A series of 2โฒโpurine and pyrimidine derivatives of 1โฒ 4โฒโanhydroโ2โฒโdeoxyโDโarabitol (1) and l',4โฒโanhydroโ2โฒโdeoxyโ__D__โaltritol (2) were synthesized regioโ and stereoโselectively from __D__โsorbitol through same conversion in high yields.