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Synthesis of 1-arylimidazoles, a new class of steroid hydroxylation inhibitors

โœ Scribed by Johnson, Alexander Lawrence; Kauer, James C.; Sharma, Dinesh Chandra; Dorfman, R. I.

Book ID
126804280
Publisher
American Chemical Society
Year
1969
Tongue
English
Weight
494 KB
Volume
12
Category
Article
ISSN
0022-2623

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A new facile method for the synthesis of
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โœ Bang-Chi Chen; Mark S Bednarz; Rulin Zhao; Joseph E Sundeen; Ping Chen; Zhongqi ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 139 KB

A new facile method for the preparation of 1-arylimidazole-5-carboxylates was developed. The new method involved reaction of anilines and ethyl glyoxylate in methanol to give a-anilino-a-methoxyacetates followed by cyclization with TosMIC, aording 1-arylimidazole-5-carboxylates in two steps in 40ยฑ94