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A new facile method for the synthesis of 1-arylimidazole-5-carboxylates

โœ Scribed by Bang-Chi Chen; Mark S Bednarz; Rulin Zhao; Joseph E Sundeen; Ping Chen; Zhongqi Shen; Amanda P Skoumbourdis; Joel C Barrish

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
139 KB
Volume
41
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A new facile method for the preparation of 1-arylimidazole-5-carboxylates was developed. The new method involved reaction of anilines and ethyl glyoxylate in methanol to give a-anilino-a-methoxyacetates followed by cyclization with TosMIC, aording 1-arylimidazole-5-carboxylates in two steps in 40ยฑ94% overall yields.

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