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Synthesis of 1-aryl-3-trifluoromethyl-5-methylthio-1,2,4-triazoles from 2-arylmethylisothiosemicarbazides and 1,1,1-trichloro-3,3,3-trifluoroacetone

✍ Scribed by Kurt H. Pilgram; Richard D. Skiles


Book ID
112127273
Publisher
Journal of Heterocyclic Chemistry
Year
1983
Tongue
English
Weight
239 KB
Volume
20
Category
Article
ISSN
0022-152X

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Syntheses of 1-(4-methylsulfonylphenyl)-
✍ F. Johari Daha; H. Matloubi; S. A. Tabatabi; B. Shafii; A. Shafiee πŸ“‚ Article πŸ“… 2005 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 60 KB

Condensation of 4-methylsulfonylaniline with aryl aldehyde in ethanol-tetrahydrofuran afforded the imino compound 3. 1,3-Cycloaddtion of diazomethane with compound 3 followed by oxidazation of the triazoline 4 with potassium permanganate gave 1-(4-methylsulfonylphenyl)-5-aryl-1,2,3-triazoles 5. Simi