## Synthesis of the title compound ( 5 ) . an histamine H2 -receptor antagonist, is described. Treatment of 3-(3-[2.6-C1-piperidinomethylphenoxv)propylamine(l)l with 3-amino-4-methoxy-l,2,5-thiadiazole-1-oxide2 produced 3-amino-4-13-0-[ 2,6-"C]piperidinomethylphenoxy)propylamino~-1,2,5-thiadiazole
Synthesis of 1-amino-2-β-(3- [2,6-14C] piperidinome thylphenoxy) propylamino -1-cyclobutene-3,4-dione hydrochloride
✍ Scribed by J. E. Swigor; A. A. Algieri; R. T. Standridge; K. A. Pittman
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- French
- Weight
- 246 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-2135
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📜 SIMILAR VOLUMES
## Abstract A convenient synthesis of the ^14^C‐labelled chloromethyl ketone analog of leucine is reported. Modification of previously published conditions allowed for the facile synthesis of: 2–^14^C‐3‐amino‐1‐chloro‐5‐methylhexan‐2‐one hydrochloride in four steps from 1‐^14^C‐DL‐leucine in 85.7%
## Abstract The title compound 9 was prepared by the route outlined in Scheme I. [^14^C]Thiourea (1) was condensed with ethyl 4‐bromo‐3‐oxo‐2‐methoxyiminoacetate (2), providing ethyl 2‐(2‐amino‐4‐[2‐^14^C]thiazolyl)‐2‐methoxyiminoacetate (3), as the pure Z‐isomer. Saponification gave the amino acid
## Abstract Modification of the traditional. Gomberg reaction conditions provides a simple, economical. route to 2‐chlorobiphenyl‐1′,2′,3′,4′,5′,6′‐^14^__C__~6~ __(I). The reaction of benzene‐U‐__^14^__C__~6~ __with an excess of the diasonium salt from__ 2__‐chloroaniline produces__ ^14^__C‐labelle