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Synthesis of 1-(8-phosphonomethoxy-3,6-dioxaoctyl)pyrimidines and purines, a novel series of acyclonucleotide analogues

✍ Scribed by Marie Charron; H. L. Allan Tse; Tarek S. Mansour; David J. Knight; Corrine O'Sullivan; Jonathan A. V. Coates

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
413 KB
Volume
5
Category
Article
ISSN
1042-7163

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✦ Synopsis

A convenient synthesis of 1 -(8-phosphonornethoxy-3,6dioxaoctyl) uracil, cytosine, adenine, and guanine nucleotide analogues 26, 28, 30, and 32 by Mitsunobu coupling of the nucleobases with suitably functionalized alcohol derivative 24 is described. The antiviral activit? o f this series of compounds against herpes simplex virus (HSV) types I and 2 and h u m a n cytomegalovirus is re,ported.

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