Synthesis of (±)-1-(2,6,6-trimethyl-4-hydroxycyclohexenyl)-1,3-butanedione (1), a marine natural product
✍ Scribed by Mauricio G. Constantino; Paulo M. Donate; Nicola Petragnani
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 191 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Herein we report an approach to the formation of 5-alkynyl-1,3-dioxin-4-ones using Suzuki-Miyaura cross-coupling reaction of potassium alkynyltrifluoroborate salts with 2,2,6-trimethyl-5-iodo-1,3dioxin-4-one. The resulting 5-ethynyltrimethylsilyl-1,3-dioxin-4-ones obtained through the Sonogashira re
## Abstract Optimized conditions are applied to the Suzuki—Miyaura cross‐coupling of potassium alkynyl trifluoroborates with the iodinated 1,3‐dioxin‐4‐one (I).
The crystal structure of the title benzofuran derivative, C~16~H~23~NO~3~, has been elucidated. The tricyclic core, __i.e.__ the tetrahydrobenzo–dihydrofuro–pyrrolidine ring system, is non-planar owing to the folding of the five-membered rings at their __cis__ junction. The cyclohexene ring assumes