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Synthesis of (1′, 2′-trans)-3-phenyl-1-[2′-(N-pyrrolidinyl)cyclohexyl]-pyrrolid-2-ones as κ-selective opiates

✍ Scribed by Chen-Yu Cheng; Hrong-Yow Lu; Fung-Mei Lee; S. William Tam


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
661 KB
Volume
79
Category
Article
ISSN
0022-3549

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Synthesis of high specific activity trit
✍ Brian R. De Costa; Andew Thurkauf; Richard R. Rothman; Arthur E. Jacobson; Kenne 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 383 KB

## Abstract Optically pure tritium labeled 1__S__,2__S__‐(‐)‐__trans__‐2‐isothiocyanato‐N‐methyl‐N‐[2‐(1‐pyrrolidinyl)cyclohexyl]benzeneacetamide, an affinity ligand specific for the kappa opioid receptor was synthesized from optically pure 1__S__,2__S__‐(‐)‐__trans__‐2‐amino‐N‐methyl‐N‐[2‐(1‐pyrro