Dolichoic acid and [1-~4C] dolichoic acid were synthesized from polyprenol isolated from the leaves of the Ginkgo biloba. Grignard coupling with 3-bromo-2-methylpropyl bcnzyl ether afforded, after deprotection, the 3-polyprenyl-2methyl propanol. The alcohol was converted into a mesylate followed by
Synthesis of [1-14C] nordolichoic acid
β Scribed by Hilde A Van Houte; Roger H Busson; Guido G Parmentier; Hendrik J Eyssen; Paul P Van Veldhoven; Guy P Mannaerts; Myriam I Baes; Peter E Declercq
- Book ID
- 107740381
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 363 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0009-3084
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## Abstract The title work proceeds in five steps and 16% overall yield from sodium [1β^14^C]acetate, which was converted by bromination followed by ethoxide displacement and reaction with phthaloyl dichloride to ethoxy[1β^14^C]acetyl chloride. The thermal[2+2]cycloaddition of tetraethoxyethene wit
## 14 A method was developed to synthesize C-labelled n-qtkanes for use in cigarette smoke studies. Specifica],ly, n-[18-Cloctatriacontane was synthesized from 1 mCi [l-Clstearic acid in a radiochemical yield of 20%. synthesis were two consecutive alkylations yf tosylmethyl isocyanide followed by
## Abstract A growing interest in the phytotoxic effects of trichloroacetic acid (TCA) has led us to develop a smallβscale (<1 mmol) oneβpot synthesis of [1,2β^14^C]TCA with >70% yield and specific activity of 3.7 GBq/mmol. Copyright Β© 2001 John Wiley & Sons, Ltd.