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Synthesis, NMR spectra and X-ray data of chloro and dichloro derivatives of 3-hydroxy-2-phenylquinolin-4(1H)-ones and their cytostatic activity

✍ Scribed by Pavel Hradil; Petr Krejčí; Jan Hlaváč; Iveta Wiedermannová; Antonín Lyčka; Valerio Bertolasi

Publisher: Journal of Heterocyclic Chemistry
Year: 2004
Tongue: English
Weight: 301 KB
Volume: 41
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570410311

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✦ Synopsis

Abstract

As known, some derivatives of quinolin‐4(1__H__)‐one possess interesting biological properties. The biological and cytostactic activity of 2‐substituted 3‐hydroxyquinolin‐4(1__H__)‐ones has not been reported yet. In this paper the synthesis of a series of chloro and dichloro 2‐phenyl‐3‐hydroxyquinolin‐4(1__H__)‐ones and their characterization by NMR spectra and X‐ray data is described. Their cytostatic properties have been evaluated and the results are reported.

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