## Abstract As known, some derivatives of quinolin‐4(1__H__)‐one possess interesting biological properties. The biological and cytostactic activity of 2‐substituted 3‐hydroxyquinolin‐4(1__H__)‐ones has not been reported yet. In this paper the synthesis of a series of chloro and dichloro 2‐phenyl‐3‐
✦ LIBER ✦
Synthesis, NMR Spectra and X-Ray Data of Chloro and Dichloro Derivatives of 3-Hydroxy-2-phenylquinolin-4(1H)-ones and Their Cytostatic Activity.
✍ Scribed by Pavel Hradil; Petr Krejci; Jan Hlavac; Iveta Wiedermannova; Antonin Lycka; Valerio Bertolasi
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 10 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The proton spectra of bicyclo[3.2.0]hept‐2‐en‐6‐one and the 7,7‐dimethyl, 7,7‐dichloro and 7‐__endo__‐chloro derivatives were analysed and the chemical shifts and coupling constants are reported. Molecular modelling and chemical shift calculations together with the observed couplings sh