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Synthesis, in silico, in vitro, and in vivo investigation of 5-[11C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2

✍ Scribed by Caballero, Julio; Muñoz, Camila; Alzate-Morales, Jans H.; Cunha, Susana; Gano, Lurdes; Bergmann, Ralf; Steinbach, Joerg; Kniess, Torsten


Book ID
119234142
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
770 KB
Volume
58
Category
Article
ISSN
0223-5234

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Angiogenesis is an important process in cell development, especially in cancer. Vascular endothelial growth factor (VEGF) signaling is an important regulator of angiogenesis. Several therapies that act against VEGF signal transduction have been developed, including YN968D1, which is a potent inhibit