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Synthesis, hypolipidemic and hypoglycemic activity of some novel 2-(4-(2-substituted aminothiazole-4-yl) phenoxy)-2-methyl propanoic acid derivatives

✍ Scribed by Santosh N. Mokale; R.D. Elgire; Nikhil Sakle; Devanand B. Shinde

Book ID
104005198
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
626 KB
Volume
21
Category
Article
ISSN
0960-894X

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✦ Synopsis

An improved synthetic protocol for a novel series of 2-(4-(2-substituted aminothiazole-4-yl) phenoxy)-2methyl propanoic acid derivatives has been developed using different methods of synthesis. The synthesized compounds are evaluated for their hypolipidemic and hypoglycemic activity by high fat diet induced hyperlipidemia and hyperglycemia in Sprague-Dawley rats.

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Microwave-Assisted Synthesis, Hypolipide
Microwave-Assisted Synthesis, Hypolipidemic and Hypoglycemic Activity of Some Novel 2-(4-(2-Amino-6-(4-substituted phenyl)-pyrimidin-4-yl)-phenoxy)-2-methyl Propanoic Acid Derivatives
✍ Santosh N. Mokale; Rupali D. Elgire; Nikhil S. Sakle; Devanand B. Shinde πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 180 KB πŸ‘ 2 views

## Abstract A novel series of aminopyrimidines containing the phenoxy isobutyric acid group as a pharmacophore was synthesized using conventional and microwave assisted methods of synthesis. The compounds were synthesized in good yields (70–89%) by the microwave‐assisted one‐pot protocol in much sh