Microwave-Assisted Synthesis, Hypolipidemic and Hypoglycemic Activity of Some Novel 2-(4-(2-Amino-6-(4-substituted phenyl)-pyrimidin-4-yl)-phenoxy)-2-methyl Propanoic Acid Derivatives

✍ Scribed by Santosh N. Mokale; Rupali D. Elgire; Nikhil S. Sakle; Devanand B. Shinde

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 180 KB
• Volume: 345
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.201000229

✦ Synopsis

Abstract

A novel series of aminopyrimidines containing the phenoxy isobutyric acid group as a pharmacophore was synthesized using conventional and microwave assisted methods of synthesis. The compounds were synthesized in good yields (70–89%) by the microwave‐assisted one‐pot protocol in much shorter reaction times. The synthesized compounds were evaluated for their hypolipidemic and hypoglycemic activity by high‐fat diet‐induced hyperlipidemia and hyperglycemia in male Sprague‐Dawley rats. The present investigation showed significant antihyperlipidemic and antihyperglycemic activity for all compounds of the series when compared with the standard drug. Structure‐activity relationship (SAR) for the series were developed by comparing total lipid profile data of synthesized compounds with fenofibrate as standard drug.