𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis, Ex Vivo Evaluation, and Radiolabeling of Potent 1,5-Diphenylpyrrolidin-2-one Cannabinoid Subtype-1 Receptor Ligands as Candidates for In Vivo Imaging

✍ Scribed by Donohue, Sean R.; Krushinski, Joseph H.; Pike, Victor W.; Chernet, Eyassu; Phebus, Lee; Chesterfield, Amy K.; Felder, Christian C.; Halldin, Christer; Schaus, John M.


Book ID
115463100
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
266 KB
Volume
51
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Synthesis and in vivo evaluation of [O-m
✍ Jaya Prabhakaran; Ramin V. Parsey; Vattoly J. Majo; Ronald L. Van Heertum; J. Jo 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 224 KB 👁 1 views

## Abstract 2‐(4‐Methoxyphenyl)‐__N__‐(4‐methylbenzyl)‐__N__‐(1‐methylpiperidin‐4‐yl)acetamide (AC90179, **4**), a highly potent and selective competitive 5‐HT~2A~ antagonist, was labeled by [^11^C]‐methylation of the corresponding desmethyl analogue **5** with [^11^C]methyl triflate. The precursor

Synthesis and in vivo evaluation in mice
✍ P. Blanckaert; I. Burvenich; F. Devos; G. Slegers 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 119 KB 👁 1 views

## Abstract This work reports the synthesis, radiolabelling and __in vivo__ evaluation in NMRI mice of [^123^I]‐(4‐fluorophenyl)[1‐(3‐iodophenethyl)piperidin‐4‐yl]methanone ([^123^I]‐3‐I‐CO) as a potential SPECT tracer for the 5‐HT~2A~ receptor. The tributylstannylprecursor was synthesized with a 1