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Radiolabeling and in vitro / in vivo evaluation of N-(1-adamantyl)-8-methoxy-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide as a PET probe for imaging cannabinoid type 2 receptor

✍ Scribed by Mu, Linjing; Bieri, Daniel; Slavik, Roger; Drandarov, Konstantin; Müller, Adrienne; Čermak, Stjepko; Weber, Markus; Schibli, Roger; Krämer, Stefanie D.; Ametamey, Simon M.

Book ID
120663418
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
743 KB
Volume
126
Category
Article
ISSN
0022-3042

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## Abstract 2‐(4‐Methoxyphenyl)‐__N__‐(4‐methylbenzyl)‐__N__‐(1‐methylpiperidin‐4‐yl)acetamide (AC90179, **4**), a highly potent and selective competitive 5‐HT~2A~ antagonist, was labeled by [^11^C]‐methylation of the corresponding desmethyl analogue **5** with [^11^C]methyl triflate. The precursor