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Synthesis, evaluation and molecular modeling of cyclic tetrapeptide histone deacetylase inhibitors as anticancer agents

โœ Scribed by Dawei Huang; Xiaohui Li; Lei Sun; Zhilong Xiu; Norikazu Nishino


Book ID
112180800
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
729 KB
Volume
18
Category
Article
ISSN
1075-2617

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Histone deacetylase inhibitors: synthesi
โœ Erinprit K. Singh; Lidia A. Nazarova; Stephanie A. Lapera; Leslie D. Alexander; ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 667 KB

Synthesis of nine macrocyclic peptide HDAC inhibitors and three triazole derivatives are described. HDAC inhibitory activity of these compounds against HeLa cell lysate is evaluated. The biological data demonstrates that incorporation of a triazole unit improves the HDAC inhibitory activity.