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Synthesis, cytotoxic activity, and thermal studies of novel N-[(1,3-diphenylpyrazol-4-yl)methyl] α-amino acids

✍ Scribed by Milan D. Joksović; Gordana Bogdanović; Vesna Kojić; Katalin Mészáros Szécsényi; Vukadin M. Leovac; Dimitar Jakimov; Snežana Trifunović; Violeta Marković; Ljubinka Joksović

Publisher: Journal of Heterocyclic Chemistry
Year: 2010
Tongue: English
Weight: 283 KB
Volume: 47
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.400

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✦ Synopsis

Abstract

magnified image New N‐[(1,3‐diphenylpyrazol‐4‐yl)methyl]α‐amino acids (1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h, 1i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT‐29, cervix carcinoma HeLa, and normal fetal lung fibroblasts, MRC‐5. Compounds derived from both phenylalanine enantiomer precursors appeared to be the most active against myelogenous leukemia K562 cell lines with a high cytotoxic potential. J. Heterocyclic Chem., (2010).

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