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Synthesis, crystal structure and molecular conformation of the tBuCO-D,L-Ala-Δz-Phe-NhiPr α,β-unsaturated dipeptide

✍ Scribed by AUBRY, ANDRE ;PIETRZYNSKI, GRZEGORZ ;RZESZOTARSKA, BARBARA ;BOUSSARD, GUY ;MARRAUD, MICHEL


Book ID
115099165
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
613 KB
Volume
37
Category
Article
ISSN
0367-8377

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To obtain general rules of peptide design using alpha, beta-dehydro-residues, a sequence with two consecutive delta Phe-residues, Boc-L-Val-delta Phe-delta Phe-L-Ala-OCH3, was synthesized by azlactone method in solution phase. The peptide was crystallized form its solution in an acetone/water mixtur

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The peptide BOC-L-Val-APhe-APhe-L-Val-OCH3 was synthesized by the azlactone method in solution phase, and its crystal and molecular structures were determined by x-ray diffraction method. Single crystals were grown by slow evaporation from a methanol/water solution at 6°C. The crystals belong to an

α,β-Dehydro-amino acid residues in the d
✍ Pushkar Sharma; Punit Narula; Tej P. Singh 📂 Article 📅 1994 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 470 KB 👁 1 views

The dehydro-residue containing peptides N-Ac-dehydro-Phe-L-Leu-OCH3 ( I ) and N-Acdehydro-Phe-NorVal-OCH, (11) were synthesized by the usual workup procedures. The peptides crystallize from their solutions in methanol in space group P6,: ( I ) a = b = 12.528(2) A, c = 21.653(5) A; (11) a = b = 12.53