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Synthesis, characterization and photocytotoxicity of a glycoconjugated meso-monoarylbenzochlorin

โœ Scribed by Philippe Maillard; Clotilde Hery; Michel Momenteau


Book ID
104257073
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
260 KB
Volume
38
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


Amphiphilic glycoconjugated benzochlorin was prepared efficiently from meso monoaryl porphyrin and 3-(dimethylamino)acrolein by regiospecific Vilsmeier's reaction followed by cyclisation under acidic conditions and glycosylation, This compound displays a good in vitro photocytotoxicity on tumor cell lines after irradiation with light > 590 nm.


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โœ P. MAILLARD; C. HERY; M. MOMENTEAU ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 28 KB ๐Ÿ‘ 1 views

Synthesis, Characterization and Photocytotoxicity of a Glycoconjugated meso-Monoarylbenzochlorin. -The title compound (I) is prepared efficiently from meso monoaryl porphyrin and 3-(dimethylamino)acrolein by a regiospecific Vilsmeier reaction followed by cyclization and glycosylation. It shows good