Synthesis, Characterization, and Pharmacokinetic Studies of PEGylated Glucagon-like Peptide-1
β Scribed by Lee, Sang-Heon; Lee, Seulki; Youn, Yu Seok; Na, Dong Hee; Chae, Su Young; Byun, Youngro; Lee, Kang Choon
- Book ID
- 121198338
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 147 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1043-1802
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π SIMILAR VOLUMES
The rapid elimination of glucagon-like peptide-1 (GLP-1) is the main impediment to its anti-diabetic utility. Here, we tried to improve its poor pharmacokinetic/pharmacodynamic profiles using PEGylation. The site-specific (Lys 34 ) PEGylated GLP-1s were synthesized with PEGs of 2, 5, and 10 kDa, res
## Abstract Peptides represent a rich natural source of potential medicines with one notable pharmaceutical limitation being their relatively short duration of action. A particularly good example of this phenomenon is glucagonβlike peptide 1 (GLP), a hormone of appreciable interest for the treatmen