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Synthesis, Characterization, and Pharmacokinetic Studies of PEGylated Glucagon-like Peptide-1

✍ Scribed by Lee, Sang-Heon; Lee, Seulki; Youn, Yu Seok; Na, Dong Hee; Chae, Su Young; Byun, Youngro; Lee, Kang Choon


Book ID
121198338
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
147 KB
Volume
16
Category
Article
ISSN
1043-1802

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The rapid elimination of glucagon-like peptide-1 (GLP-1) is the main impediment to its anti-diabetic utility. Here, we tried to improve its poor pharmacokinetic/pharmacodynamic profiles using PEGylation. The site-specific (Lys 34 ) PEGylated GLP-1s were synthesized with PEGs of 2, 5, and 10 kDa, res

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