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Synthesis, characterization and in vitro release of 5-aminosalicylic acid and 5-acetyl aminosalicylic acid of polyanhydride – P(CBFAS)

✍ Scribed by Q.X Cai; K.J Zhu; D Chen; L.P Gao

Book ID
117639429
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
176 KB
Volume
55
Category
Article
ISSN
0939-6411

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5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized and their properties as colon-speci®c prodrugs of 5aminosalicylic acid (5-ASA) were investigated employing rats as test animals. Incubation of 5-ASA-Asp and 5-ASA-Glu with the homogenates of ti