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Radical-derived oxidation products of 5-aminosalicylic acid and N-acetyl-5-aminosalicylic acid

โœ Scribed by C. Fischer; U. Klotz


Book ID
103805477
Publisher
Elsevier Science
Year
1994
Weight
882 KB
Volume
661
Category
Article
ISSN
0378-4347

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5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized and their properties as colon-speciยฎc prodrugs of 5aminosalicylic acid (5-ASA) were investigated employing rats as test animals. Incubation of 5-ASA-Asp and 5-ASA-Glu with the homogenates of ti