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Stability of 5-aminosalicylic acid and 5-acetylaminosalicylic acid in plasma

✍ Scribed by E. Brendel; I. Meineke; E. Stüwe; H. Osterwald


Book ID
108447857
Publisher
Elsevier Science
Year
1988
Weight
290 KB
Volume
432
Category
Article
ISSN
0378-4347

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5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized and their properties as colon-speci®c prodrugs of 5aminosalicylic acid (5-ASA) were investigated employing rats as test animals. Incubation of 5-ASA-Asp and 5-ASA-Glu with the homogenates of ti