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Synthesis, characterization and in vitro antitumor activity of dimethyl-, diethyl, and di-t-butyl-tin(IV) derivatives of substituted salicylic acids

✍ Scribed by Mohammed Bouâlam; Rudolph Willem; Monique Biesemans; Marcel Gielen

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
551 KB
Volume
5
Category
Article
ISSN
0268-2605

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✦ Synopsis

The synthesis of dimethyl-, diethyl-and/or di-tbutyl-tin(1V) derivatives of substituted salicylic acids of the type a, (X-Y-2-OH-C6H,C00) , 3-CH30; H, 5-CH30; 3-CH3, 6-(CH,),CH; 3,5-[(CH3)2CH]2 and 4,S-benzo) and b {[R2(X-Y-2-OH-C6H,COO)Sn]zO}2 (X, Y = H, 3,5-[(CH3),CH], and 4,S-benzo) is reported. Their characterization by 'H, I3C and 'I9Sn NMR, Mossbauer and mass spectrometry is described. The in uitro antitumor activity of selected derivatives against two human tumoral cell lines, MCF-7 and WiDr, is presented.

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