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Synthesis, characterization, and evaluation of antimicrobial activities of a new class of macrocyclic phosphonates

✍ Scribed by G. Chandra Sekhar Reddy; A. Uma Ravi Sankar; M. Veera Narayana Reddy; C. Radha Rani; C. Suresh Reddy

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
117 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A series of a new class of phosphorus analogue macrocycles was accomplished by condensation of N‐substituted‐[bis(3,5‐dimethyl‐2‐hydroxybenzyl)]‐amines with various phosphorus dichlorides in dry toluene in the presence of triethylamine at 0–50°C. All the title compounds were evaluated for antimicrobial activity to determine their efficacy and were effective in suppressing the growth of bacteria and fungi. The chemical structures of the title products were characterized by IR, ^1^H, ^13^C, ^31^P‐NMR, mass spectral studies, and elemental analysis. J. Heterocyclic Chem., (2011).

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