Synthesis, characterization and comparative study of aminophosphonate chelates of gadolinium(III) ions as magnetic resonance imaging contrast agents
โ Scribed by S.W.Annie Bligh; Charles T. Harding; Andrew B. McEwen; Peter J. Sadler; J.Duncan Kelly; Janet A. Marriott
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 677 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0277-5387
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Scheme 1. Reduction-controlled condensation of 1 to assemble gadolinium-containing nanoparticles (Gd NPs). Compound 2 is the control probe that cannot be reduced to induce condensation. [
The introduction of a lipophilic moiety into the gadolinium chelate Gd-DTPA (dimeglumine gadopentetate, Magnevist) yielded Gd-EOB-DTPA (short form), which has potential as a magnetic resonance contrast agent for liver mass screening. The pharmacokinetics of Gd-EOB-DTPA in rats is nonlinear because a