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Controlled Self-Assembling of Gadolinium Nanoparticles as Smart Molecular Magnetic Resonance Imaging Contrast Agents

✍ Scribed by Dr. Gaolin Liang; Dr. John Ronald; Dr. Yuanxin Chen; Dr. Deju Ye; Dr. Prachi Pandit; Man Lung Ma; Prof. Brian Rutt; Prof. Jianghong Rao

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
502 KB
Volume
123
Category
Article
ISSN
0044-8249

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✦ Synopsis

Scheme 1. Reduction-controlled condensation of 1 to assemble gadolinium-containing nanoparticles (Gd NPs). Compound 2 is the control probe that cannot be reduced to induce condensation. [

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## Abstract A new macromolecular gadolinium‐based magnetic resonance imaging (MRI) contrast agent, folic acid (FA)–poly(ethylene glycol) (PEG)–polyamidoamine dendrimer (PAMAM)–Gd, was synthesized with a core of PAMAM, which was modified with conjugates of FA and PEG and then chelated by gadolinium