Synthesis, characterization and biological activity of C60 derivative

✍ Scribed by Guichang Jiang; Guangtao Li

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 172 KB
• Volume: 104
• Category: Article
• ISSN: 0021-8995
• DOI: 10.1002/app.26126

✦ Synopsis

Abstract

A novel fullerene**‐**maleic anhydride derivative was synthesized via radical polymerization. It is soluble in polar solvents such as water, dimethyl sulfoxide, and tetrahydrofuran etc. The product was characterized by FTIR, UV‐Vis, GPC, and Transmission electron microscope (TEM). TEM analysis shows that the average particle diameter is about 38 nm. The in vitro antitumor activity of the fullerene‐maleic anhydride derivative has been tested and the result shows that the derivative exhibits better antitumor activity against HeLa cells and bone tumor cells. To prove water‐soluble fullerene derivatives photodynamic effect on tumor cell, i.e., the photodynamic effect on mouse bone tumor in vivo we injected the fullerene ‐maleic anhydride derivatives into the mouse bone tumor body. We found that with I‐W lamp (500 W) illumination the mouse bone tumor body was strongly damaged. The antitumor mechanism of water‐soluble fullerene‐maleic anhydride derivative was investigated for the first time. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007