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Synthesis, characterization and biodistribution of the cationic technetium(II), 1,10-phenanthroline chelate

✍ Scribed by K. Schwochau; K.H. Linse; Z.F. Su

Publisher
Elsevier Science
Year
1992
Weight
343 KB
Volume
43
Category
Article
ISSN
0883-2889

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✦ Synopsis

[99Tc(phen)3]Cl2 was synthesized by reduction of pertechnetate with sodium borohydride in the presence of an excess of 1,10-phenanthroline and characterized by FAB mass spectrometry, magnetic susceptibility measurements, and i.r./vis/u.v. spectrophotometry. For biodistribution evaluation in mice [99mTc(phen)3]Cl2 could be obtained in a radiochemical purity of 92.5% using a similar procedure. The rather hydrophilic chelate was predominantly excreted by the kidneys. Its low blood retention resulted in a heart/blood activity ratio of 4.2 at 100 min post-injection.

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