Preparation, characterization and organ distribution of the oxochloro-BIS-(1,10-phenanthroline)technetium (V) cation

✍ Scribed by K. Schwochau; K. H. Linse; P. Pleger; U. Pleger; C. Kremer; A. A. de Graaf

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: French
• Weight: 337 KB
• Volume: 38
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/(sici)1099-1344(199611)38:11<1031::aid-jlcr919>3.0.co;2-z

✦ Synopsis

4, Erdol und Organische Geochemie, Forschungszentrum Julich GmbH (KFA), D-52425 Jiilich, Geimany SUMMARY [T~OCl(phen)~]Cl~ was prepared by controlled potential cathodic reduction or dithionite reduction of TcOi in aqueous alcoholic solution containing 1,lO-phenanthroline(phen) monohydrate. The compound was also obtained by ligand exchange reaction of [TcOClJ with phen-H2O in methanol. The strong IR absorption at 895 cm-' was attributed to the Tc=O stretching vibration. The 'H NMR spectrum

displayed 16 distinct resonances which were assigned by HH-COSY-experiments to the non-equivalent aromatic protons of the two phen ligands. The maximum uptake of [99"TcOC1@hen)2]2+ of 4.2 % dose/g heart in mice, 1 min p i , was low, probably reflecting the dipositive charge and the high hydrophilicity of the complex.