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Synthesis, characterization, and antimicrobial activity of 3′-(4-(2-substituted thiazol-4-yl)phenyl)spiro[indoline-3,2′-thiazolidine]-2,4′-diones

✍ Scribed by Pravin C. Mhaske; Shivaji H. Shelke; Rahul P. Jadhav; Hemant N. Raundal; Sachin V. Patil; Amar A. Patil; Vivek D. Bobade

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
119 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image A series of 3′‐(4‐(2‐methyl/phenyl/benzylthiazol‐4‐yl)phenyl)spiro[indoline‐3,2′‐thiazolidine]‐2,4′‐diones was synthesized. The structures of the synthesized compounds were evaluated by analytical and spectral (IR, ^1^H NMR, ^13^C NMR, LC‐MS, and elemental analysis) methods. All the synthesized compounds were screened for qualitative (Zone of inhibition) and quantitative antimicrobial activities (MIC). Most of the derivatives showed good activity towards Gram‐positive and Gram‐negative bacteria. J. Heterocyclic Chem., (2010).

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## Abstract magnified image Some new derivatives of spiro[3__H__‐indole‐3,2′‐thiazolidine]‐2,4′(1__H__)‐dione with the heterocyclic ring such as substituted thiazole and 1,2,4‐oxadiazole attached to the indolinone ring __via__ CH~2~ linkage has been synthesized in moderate yields. The synthesis ha