✦ LIBER ✦

Synthesis, characteristic spectral studies and in vitro antimicrobial and antitumour activities of organotin(IV) complexes of Schiff bases derived from amino-acids

✍ Scribed by Mala Nath; Rakesh Yadav; Marcel Gielen; Hassan Dalil; Dick de Vos; G. Eng

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 129 KB
Volume: 11
Category: Article
ISSN: 0268-2605
DOI: 10.1002/(sici)1099-0739(199709)11:9<727::aid-aoc639>3.0.co;2-x

No coin nor oath required. For personal study only.

✦ Synopsis

Equimolar reactions of dibutyltin(IV) oxide with Schiff bases derived from amino-acids led to the formation of a new series of dibutyltin(IV) complexes of general formula, Bu 2 SnL [L = dianion of tridentate Schiff bases derived from the condensation of 2-hydroxy-1-naphthaldehyde or acetyl acetone with glycine (L-1), L-␤-alanine (L-2), DL-valine (L-3), DL-4-aminobutyric acid (L-4), L-methionine (L-5), L-leucine (L-6) and phenylglycine (L-7)]. An attempt has been made to prove the structures of the resulting complexes on the basis of elemental analyses, conductance measurements and electronic, IR, multinuclear magnetic resonance ( 1 H, 13 C and 117 Sn) and 119 Sn Mössbauer spectral studies. The complexes have been tested against various bacteria [streptococcus faecalis, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus penicillin resistance (2500 units)] and fungi (Candida albicans, Cryptococcus neoformans, Sporotrichum schenckii, Trichophyton mentagrophytes and Aspergillus fumigatus). All the complexes showed moderate activity. The cytotoxicity of a few compounds has been screened in vitro against seven human tumour cell lines, viz. MCF-7, EVSA-T, WiDr, IGROV, M19 MEL, A498 and H226. The activities found experimentally were better than those obtained for cisplatin and carboplatin.

📜 SIMILAR VOLUMES

Characteristic spectral studies and in v

Characteristic spectral studies and in vitro Antimicrobial and in vivo multi-infection antifungal activities in mice of new organotin(IV) derivatives of heterocyclic amino acids

✍ Mala Nath; Rakesh Yadav; G. Eng; P. Musingarimi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 91 KB 👁 1 views

The nature of the products obtained on reacting R 3 SnCl (R = Me, Bu and Ph), Ph 2 SnCl 2 and Bu 2 SnO with amino acids having nitrogencontaining heterocyclic rings; i.e. L-histidine and DL-tryptophan, is shown to depend upon the reaction conditions. Ten new organotin(IV) derivatives of these amino

Synthesis and spectroscopic studies of o

Synthesis and spectroscopic studies of organotin(IV) complexes of biologically active Schiff bases derived from sulpha drugs

✍ Har Lal Singh; S. Varshney; A. K. Varshney 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 64 KB 👁 1 views

The reaction of dibutyltin oxide with Schiff bases derived from sulpha drugs in 1:1 molar ratio leads to the formation of a new series of organotin(IV) complexes. An attempt has been made to probe their structure on the basis of UV, IR, NMR ( 1 H, 13 C and 119 Sn) and Mo ¨ssbauer spectral studies. A