Characteristic spectral studies and in vitro Antimicrobial and in vivo multi-infection antifungal activities in mice of new organotin(IV) derivatives of heterocyclic amino acids

✍ Scribed by Mala Nath; Rakesh Yadav; G. Eng; P. Musingarimi

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 91 KB
• Volume: 13
• Category: Article
• ISSN: 0268-2605
• DOI: 10.1002/(sici)1099-0739(199901)13:1<29::aid-aoc809>3.0.co;2-d

✦ Synopsis

The nature of the products obtained on reacting R 3 SnCl (R = Me, Bu and Ph), Ph 2 SnCl 2 and Bu 2 SnO with amino acids having nitrogencontaining heterocyclic rings; i.e. L-histidine and DL-tryptophan, is shown to depend upon the reaction conditions. Ten new organotin(IV) derivatives of these amino acids have been synthesized and characterized by elemental analyses, molar conductance and electronic spectra, and the bonding in these complexes is discussed in terms of their infrared, far-infrared, 1 H and 13 C NMR, and 119 Sn Mo ¨ssbauer spectra. The complexes soluble in DMSO have been tested in vitro against a wide spectrum of bacteria and fungi and found to be active. Two complexes, Ph 3 SnL-1 and Ph 3 SnL-2, have been found to be slightly active in vivo against a multiinfection fungal model in mice.