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Synthesis, biodistribution and PET studies in rats of 18F-Labeled bridgehead fluoromethyl analogues of WAY-100635

✍ Scribed by Rana Al Hussainy; Joost Verbeek; Dion van der Born; Carla Molthoff; Jan Booij; J. (Koos) D.M. Herscheid


Book ID
119334590
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
730 KB
Volume
39
Category
Article
ISSN
0969-8051

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## Abstract The present study demonstrated the synthesis and __in vivo__ study of ^18^F‐labeled __N__‐(4‐acetyl‐1‐piperazinyl)‐__p__‐fluorobenzamide (FK960) which is a novel anti‐dementia drug candidate. [^18^F]FK960 was prepared by a one‐pot, three reaction sequence, using nucleophilic fluorinatio