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Semiautomated synthesis of a novel [18F] amine fluorocyanoborane for PET imaging studies. Radiosynthesis and in vivo characterization in rats

✍ Scribed by Eli Shalom; Khuloud Takrouri; Nir Metsuyanim; Arik Grufi; Jehoshua Katzhendler; Morris Srebnik


Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
565 KB
Volume
65
Category
Article
ISSN
0969-8043

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## Abstract A convenient synthesis of [N‐methyl‐^11^C]‐3‐[(6‐dimethylamino)pyridin‐3‐yl]‐2,5‐dimethyl‐__N__,__N__‐dipropylpyrazolo[1,5‐a]pyrimidine‐7‐amine (R121920), a highly selective CRF~1~ antagonist has been developed as a potential PET ligand. 3 ‐ [(6 ‐ methylamino)pyridin ‐ 3 ‐ yl]‐2,5‐dimet