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Synthesis, binding and fluorescence properties of oligonucleotide derivatives having a dansyl fluorescence label attached to the 2′-position of a ribonucleoside

✍ Scribed by Kazushige Yamana; Yoshihito Ohashi; Kenji Nunota; Hidehiko Nakano


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
361 KB
Volume
53
Category
Article
ISSN
0040-4020

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Synthesis of oligonucleotide derivatives
✍ Kazushige Yamana; Mizuki Takei; Hidehiko Nakano 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 248 KB

The synthesis of a pyrene labeled glycerol linker for multiple internal labeling of oligonucleolides has been described. The ofigonucleotide containing two successively incorporated pyrenyl residues exhibits enhanced excimer fluorescence upon hybridization to the complements~ DNA segment.