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Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1-Substituted Tetrahydroisoquinolines

✍ Scribed by Dohle, Wolfgang; Leese, Mathew P.; Jourdan, Fabrice L.; Major, Meriel R.; Bai, Ruoli; Hamel, Ernest; Ferrandis, Eric; Kasprzyk, Philip G.; Fiore, Ann; Newman, Simon P.; Purohit, Atul; Potter, Barry V. L.


Book ID
121876864
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
671 KB
Volume
9
Category
Article
ISSN
1860-7179

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Synthesis and Screening of C1-Substitute
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## Abstract Tetrahydroisoquinoline (TIQ) derivatives exhibit good biological activity. However, utilization of TIQ compounds in asymmetric catalysis is limited. This paper presents a series of TIQ derivatives in asymmetric transfer hydrogenation (ATH) reactions. Chiral TIQ amino alcohol ligands wer